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T. V. Rao ¹, S. Vidhyadhara ², K. R. S. Sambasivarao ³

Affiliations
1 Bapatla College of Pharmacy, Bapatla, Guntur District, Andhra Pradesh- 522101, IN
2 Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, IN
3 Deportment of Biotechnology, Achrya Nagarjuna University, Gunter, Andhra Pradesh., IN

Abstract

The objective of this research was to formulate and evaluate the Indomethecin microcapsules for controlled drug delivery by emulsification solvent evaporation technique, employing Eutragit RL100 as coating material. Prepared microcapsules were evaluated for average particle size, Flow properties, Microencapsulation efficiency and invitro drug release studies. The drug-polymer interaction evaluated by FT-IR spectroscopy. They were found to be discrete, free flowing high percentage of drug entrapment efficiency and also retard the release for 12 hrs. The in vitro dissolution study confirmed that the formulations followed zero order kinetics and peppas release mechanism.

Keywords

Indomethacin, Eudragit RL 100,MicroCapsues,FT-IR.

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K. Haritha ¹, K. R. S. Sambasivarao ¹

Affiliations
1 Centre for Biotechnology, Acharya Nagarjuna University, Guntur (A.P.), IN

Abstract

Phytases catalyse the hydrolytic degradation of phytic acid and its salts and are added to monogastric animal feed to ameliorate the negative environmental and nutritional consequences of dietary phytate. Improvement of phytase production by submerged fermentation from Rhizopus oligosporus 556 strain using 1% wheat bran was attempted by optimizing the culture medium. The phytase activity appeared to be more after 8 days of fermentation Maximum phytase production was 39U/ml after under optimal conditions i.e. 5%glucose and 0.5% of peptone at pH 6. Phytase production was affected by inorganic phosphate content and high levels of inorganic phosphorus repress the biosynthesis of phytase.

Keywords

Phytase, Rhizopus Oligosporus556, Submerged Fermentation, Phytate Degradation.

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